Journal of Dental and Allied Sciences

REVIEW ARTICLE
Year
: 2013  |  Volume : 2  |  Issue : 2  |  Page : 66--70

Matrix Metalloproteinases & Implication in Periodontitis- A Short Review


Hitesh Desarda, Subodh Gaikwad 
 Post-graduate student, Department of Periodontology, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India

Correspondence Address:
Hitesh Desarda
Post-graduate student, Department of Periodontology, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra
India

Matrix metalloproteinases (MMPs) are a group of enzymes which are responsible for the degradation of extracellular matrix during normal tissue turnover and also during inflammatory processes. The expression and activity of MMPs in adult tissues is normally quite low, but increases significantly in various pathological conditions that may lead into unwanted tissue destruction,such as inflammatory diseases, tumour growth and metastasis. The role of MMP-8 in periodontitis is the well-known example of the unwanted tissue destruction related to increased activity of MMPs. Degradation of the extracellular matrix may involve four distinct pathways. A body of evidence suggests that matrix components may be dissolved by extracellular matrix metalloproteinase (MMP)-dependent or plasmin (Pln)-dependent cleavage reactions and that larger fragment of matrix may be disposed by a phagocytic pathway by way of cleavage by lysosomal proteinases. Mineralized matrices appear to be degraded by a complex process mediated by osteoclasts which relies on degradation by lysosomal proteinases in a narrow pericellular compartment. Matrix metalloproteinases can specifically cleave and degrade collagens and connective tissue matrix at physiologic pH and temperature. The objective of this review article is to understand the complete mechanisms regulating the expression of MMPs and enzymatic activity is of great importance.Source for all the articles is electronic Pub-Med system, published in between 1997-2011 searched by using keywords like Matrix Metalloproteinases, Periodontitis, Extracellular Matrix, Collagen . Future trend should be directed towards the development of easy, reliable and fast diagnostic tools and the effective therapeutic strategies to reduce the levels of MMPs.


How to cite this article:
Desarda H, Gaikwad S. Matrix Metalloproteinases & Implication in Periodontitis- A Short Review.J Dent Allied Sci 2013;2:66-70


How to cite this URL:
Desarda H, Gaikwad S. Matrix Metalloproteinases & Implication in Periodontitis- A Short Review. J Dent Allied Sci [serial online] 2013 [cited 2020 Feb 19 ];2:66-70
Available from: http://www.jdas.in/article.asp?issn=2277-4696;year=2013;volume=2;issue=2;spage=66;epage=70;aulast=Desarda;type=0